|
KMID : 0811720140180020163
|
|
Korean Journal of Physiology & Pharmacology
2014 Volume.18 No. 2 p.163 ~ p.168
|
|
|
Regular Exercise Training Increases the Number of Endothelial Progenitor Cells and Decreases Homocysteine Levels in Healthy Peripheral Blood
|
|
Choi Jeong-Kyu
Moon Ki-Myung
Jung Seok-Yun
Kim Ji-Yong
Choi Sung-Hyun
Kim Da-Yeon
Kang Song-Hwa
Chu Chong-Woo
Kwon Sang-Mo
|
|
|
Abstract
|
|
|
|
Endothelial progenitor cells (EPCs) are known to play an important role in the repair of damaged blood vessels. We used an endothelial progenitor cell colony-forming assay (EPC-CFA) to determine whether EPC numbers could be increased in healthy individuals through regular exercise training. The number of functional EPCs obtained from human peripheral blood-derived AC133 stem cells was measured after a 28-day regular exercise training program. The number of total endothelial progenitor cell colony-forming units (EPC-CFU) was significantly increased compared to that in the control group (p=0.02, n=5). In addition, we observed a significant decrease in homocysteine levels followed by an increase in the number of EPC-CFUs (p=0.04, n=5), indicating that the 28-day regular exercise training could increase the number of EPC colonies and decrease homocysteine levels. Moreover, an inverse correlation was observed between small-endothelial progenitor cell colony-forming units (small-EPC- CFUs) and plasma homocysteine levels in healthy men (r=－0.8125, p=0.047). We found that regular exercise training could increase the number of EPC-CFUs and decrease homocysteine levels, thus decreasing the cardiovascular disease risk in men.
|
|
|
KEYWORD
|
|
|
Endothelial progenitor cells, EPC, Exercise, Homocysteine, Regular exercise training
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|